The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART.

摘要: Objective: To determine the impact of depressive symptoms on mortality among HIV/ AIDS patients first initiating HAART and potential role patient adherence as a confounder effect modifier in this association. Methods: The study comprised HIV-positive individuals who were prescribed between August 1996 June 2002. Depressive assessed using Center for Epidemiologic Studies Depression Scale. Cox proportional hazards models used to association symptoms, all-cause while controlling several baseline confounding factors. Results: A total 563 participants met inclusion criteria. Of these subjects, 51% had at 23% less than 95% adherent year follow-up. overall rate was 10%. Multivariate analysis showed that with < 5.90 times (95% confidence interval, 2.55-13.68) more likely die no symptoms. estimated median model-based survival probabilities stratified by levels ranged from 81 % (interquartile range, 72-89%) 97% 94-98%) ≥ 95%. Conclusion: results indicate both associated shorter HIV accessing HAART. Given high prevalence strong adherence, findings support improvement diagnosis treatment depression well order maximize effectiveness