The role of vitamin D in reducing gastrointestinal disease risk and assessment of individual dietary intake needs: Focus on genetic and genomic technologies

摘要: With the endogenous formation of vitamin D being significantly curtailed because public awareness skin cancer dangers, attention is turning to dietary sources. Cumulative evidence has implicated deficiency in increasing susceptibility various gastrointestinal disorders, including colorectal cancer, inflammatory bowel diseases, diverticulitis, and irritable syndrome. There also reason suggest adjunct therapy for such diseases. Although there justification intake overall, optimal intakes will vary among individuals. Genomic technologies have revealed several hundreds genes associated with actions. The nature these emphasizes potentially negative implications modulating absence complementary human genetic genomic data, information on gut microbiome. However, we are not yet a position apply this information. data (transcriptomics, metabolomics, proteomics, metagenomics) could provide that sufficiency been achieved. We an increasingly strong case considering more widespread use fortified foods and/or supplements benefit health. levels might beneficially be informed by personalized information, disease prevention maintenance remission.