Comparison of Complete Pathologic Response and Hepatic Injuries Between Hepatic Arterial Infusion and Systemic Administration of Oxaliplatin in Patients with Colorectal Liver Metastases

摘要: Whether hepatic arterial infusion (HAI) of oxaliplatin influences the rates complete pathologic response (CPR) and severe oxaliplatin-related lesions (SOxL) in patients with colorectal liver metastases (CRLM) is unknown. This study aimed to compare incidence CPR SOxL between systemic (intravenous, IV) HAI administration. All initially unresectable CRLM who had undergone resection two expert centers 2004 2010 after at least 6 cycles oxaliplatin-based chemotherapy administered either via (n = 18) or IV (n = 50) were included. The presence evaluated by pathologists. A 1:2 case match using a propensity score was used. observed significantly more often (33 vs. 10 %, P = 0.03). However, occurred frequently group versus group, 66 20 %, respectively (P < 0.001). On well-balanced cohort, associated higher chance (odds ratio 9.33, 95 % confidence interval 1.59–54.7) but also risk 13.7, 3.08–61.3). markedly enhanced overall survival (OS) disease-free (median OS 114 42 months, P = 0.02; median 51 12 months, P = 0.002). Patients did not experience different outcome 42 50 months, respectively; P = 0.92) increases likelihood cost CRLM.