Fibromyalgia: a stress disorder? Piecing the biopsychosocial puzzle together.

摘要: Fibromyalgia (FM) is a controversial syndrome, characterised by persistent widespread pain, abnormal pain sensitivity and additional symptoms such as fatigue sleep disturbance. The syndrome largely overlaps with other functional somatic disorders, particularly chronic (CFS). Although the exact aetiology pathogenesis of FM are still unknown, it has been suggested that stress may play key role in syndrome. This article first reviews function response system, placing special emphasis on relationships between adverse life experiences, regulation pain-processing mechanisms, summarising evidence for possible aetiopathogenetic FM. Finally, an integrative biopsychosocial model conceptualises disorder proposed, clinical research implications discussed.