Nicotine detoxification of rutin, quercitrin, and chlorogenic acid isolated from Houttuynia cordata by reducing reactive oxygen species and inducing conversion from nicotine to cotinine
作者： Kyeong Mu Kim , Soon-Mi Shim
DOI: 10.1007/S13765-014-4182-1
关键词:
摘要: The hypothesis of the present study is that methanol extract Houttuynia cordata Thunb (MEH) and its targeted bioactive components including rutin, quercitrin, chlorogenic acid can be effective in reducing reactive oxygen species (ROS) caused by nicotine promoting to cotinine HepG2 cell. Oxygen radical absorbance capacity (ORAC) MEH was measured assess free scavenging capacity. ROS inhibition ability 2′,7′-dichlorodihydrofluorescein diacetate assay. conversion rate determined direct barbiturate assay method. ORAC value confirmed provided an antioxidant ranging from 126 138 μMtrolox equivalents/100 g. Compared only, pretreatment MEH, quercitrin revealed effectively inhibit production cell up 9, 7.4, 14%, respectively. Nicotine after 120 min incubation 1.7 1.4 times higher rutin than control, H. could a valuable natural ingredient for inhibiting formation as well enhancing turnover.
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