Somatic activation of rasK gene in a human ovarian carcinoma
作者： L. Feig , R. Bast , R. Knapp , G. Cooper
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摘要: A tumor isolate from a patient with serous cystadenocarcinoma of the ovary contained an activated rasK gene detected hy transfection NIH/3T3 cells. In contrast, DNA normal cells same lacked transforming activity, indicating that activation this was consequence somatic mutation in neoplastic The product displayed electrophoretic mobility sodium dodecyl sulfate-polyacrylamide gels differed mobilities proteins other tumors, previously undescribed responsible for ovarian carcinoma.
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