Microsatellite alteration in multiple primary lung cancer

摘要: Patients with pulmonary neoplasms have an increased risk for developing a second tumor of the lung, either at same time or different times. It is important to determine if represents independent primary recurrence/metastasis, because it will significantly change management and prognosis. Microsatellite instability (MSI) loss heterozygosity (LOH) molecular disorders acquired by cell during neoplastic transformation. Both are associated genetic instability. Functional silencing tumour suppressor genes may be consequence genomic instability, particularly globally occurring LOH phenomenon. Numerous studies confirmed role MSI/LOH both early late stages multiple lung cancer. This paper reviews published literatures focused on significance in Additionally, new method based allelic variations polymorphic microsatellite markers was offered that does not rely collection normal tissue, performed minimal sample, complement clinical criteria diagnostic discrimination between cancers versus solitary metastatic diseases.