Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.
作者： Lisa Héron-Milhavet , Martin Haluzik , Shoshana Yakar , Oksana Gavrilova , Stephanie Pack
DOI: 10.1210/EN.2003-1543
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摘要: Insulin resistance is one of the primary characteristics type 2 diabetes. Mice overexpressing a dominant-negative IGF-I receptor specifically in muscle (MKR mice) demonstrate severe insulin with high levels serum and tissue lipids eventually develop diabetes at 5–6 wk age. To determine whether lipotoxicity plays role progression disease, we crossed MKR mice fatty acid translocase, CD36, skeletal muscle. The double-transgenic MKR/CD36 showed normalization hyperglycemia hyperinsulinemia as well marked improvement liver sensitivity. also exhibited normal rates oxidation when compared decreased rate MKR. With reduction resistance, β-cell function returned to normal. These other results suggest that associated increased triglycerides a...
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Chang An Chu, Dana K. Sindelar, Doss W. Neal, Alan D. Cherrington, Hepatic and gut clearance of catecholamines in the conscious dog Metabolism. ,vol. 48, pp. 259- 263 ,(1999) , 10.1016/S0026-0495(99)90044-6
O. Gavrilova, L. R. Leon, B. Marcus-Samuels, M. M. Mason, A. L. Castle, S. Refetoff, C. Vinson, M. L. Reitman, Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 14623- 14628 ,(1999) , 10.1073/PNAS.96.25.14623
G Mingrone, G Rosa, P Di Rocco, M Manco, E Capristo, M Castagneto, R Vettor, G Gasbarrini, AV Greco, Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement. International Journal of Obesity. ,vol. 26, pp. 1165- 1172 ,(2002) , 10.1038/SJ.IJO.0802053
B. D. Hegarty, S. M. Furler, J. Ye, G. J. Cooney, E. W. Kraegen, The Role of Intramuscular Lipid in Insulin Resistance Acta Physiologica Scandinavica. ,vol. 178, pp. 373- 383 ,(2003) , 10.1046/J.1365-201X.2003.01162.X
Kitt F Petersen, Gerald I Shulman, Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. American Journal of Cardiology. ,vol. 90, pp. 11- 18 ,(2002) , 10.1016/S0002-9149(02)02554-7
Azeddine Ibrahimi, Arend Bonen, W. Dennis Blinn, Tahar Hajri, Xin Li, Kai Zhong, Roger Cameron, Nada A. Abumrad, Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin. Journal of Biological Chemistry. ,vol. 274, pp. 26761- 26766 ,(1999) , 10.1074/JBC.274.38.26761
G. Perseghin, S. Ghosh, K. Gerow, G. I. Shulman, Metabolic Defects in Lean Nondiabetic Offspring of NIDDM Parents: A Cross-Sectional Study Diabetes. ,vol. 46, pp. 1001- 1009 ,(1997) , 10.2337/DIAB.46.6.1001
D. J. Drucker, M. B. Wheeler, R. A. Pederson, M. Satkunarajah, C. H. McIntosh, L. A. Scrocchi, D. Flamez, F. Schuit, Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice. Diabetes. ,vol. 47, pp. 1046- 1052 ,(1998) , 10.2337/DIABETES.47.7.1046
Loranne Agius, Matthew Peak, Christopher B. Newgard, Anna M. Gomez-Foix, Joan J. Guinovart, Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis Journal of Biological Chemistry. ,vol. 271, pp. 30479- 30486 ,(1996) , 10.1074/JBC.271.48.30479
Rohit N Kulkarni, Jens C Brüning, Jonathon N Winnay, Catherine Postic, Mark A Magnuson, C.Ronald Kahn, Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes Cell. ,vol. 96, pp. 329- 339 ,(1999) , 10.1016/S0092-8674(00)80546-2