Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
作者： Rohit N Kulkarni , Jens C Brüning , Jonathon N Winnay , Catherine Postic , Mark A Magnuson
DOI: 10.1016/S0092-8674(00)80546-2
关键词: Insulin oscillation 、 Insulin receptor 、 Insulin 、 Downregulation and upregulation 、 Insulin receptor substrate 、 Internal medicine 、 Insulin resistance 、 IRS2 、 Beta cell 、 Biology 、 Endocrinology
摘要: … we examined the insulin secretion pattern in β cell insulin receptor knockout (β IRKO) mice using nutrient stimulants commonly employed in assessing the first-phase insulin secretion in …
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