Blood Pressure Variability: Assessment, Predictive Value, and Potential as a Therapeutic Target

摘要: A large body of evidence has consistently supported the relationship between blood pressure (BP) levels and risk cardiovascular complications. In recent years, several independent studies have also indicated that this may not only depend on magnitude elevation per se but presence other associated conditions such as increased variability. This concept been by a series reports, most which post hoc analyses clinical trials in hypertension, showing increasing values BP variability (BPV) (either short term, midterm, or long term) predict development, progression, severity cardiac, vascular, renal organ damage, well events mortality. Remarkably, conducted populations at high shown BPV individual subjects (so-called intra- within-individual BPV) to be strong predictors morbidity mortality, even larger extent than average values. However, low moderate risk, contribution prediction over beyond moderate. The aim paper is critically review addressing prognostic relevance different components yet open question, i.e., whether routine assessment practice should regarded an additional target antihypertensive treatment improve protection.