Reduced hepatic α-tocopherol content after long-term administration of ethanol to rats

摘要: We have studied the effects of long-term administration ethanol on distribution and pharmacokinetics α-tocopherol. In rats fed (35% total energy) for 5–6 weeks concentration α-tocopherol in whole liver was reduced by 25% as compared to pair-fed controls (P < 0.003). This reduction significant parenchymal cells (28%, P 0.004), whereas no difference observed nonparenchymal cells. Mitochondrial content 55% ethanol-treated 0.002), microsomes, light mitochondria or cytosol. The serum levels showed between groups. When vivo labeled chylomicron α-[3H]tocopherol injected intravenously anesthetized rats, we found a increase half-life group 0.025). Hepatic similar two groups 24 h after injection.