In vitro human epidermal penetration of 1-bromopropane.
作者： H. Frederick Frasch , G. Scott Dotson , Ana M. Barbero
DOI: 10.1080/15287394.2011.595666
关键词:
摘要: 1-Bromopropane (1-BP; CAS number 106-94-5), also known as n-propyl bromide, is a halogenated short-chain alkane used an organic solvent with numerous commercial and industrial applications, including garment dry cleaning vapor degreasing of metals. The purpose this study was to determine the dermal absorption characteristics corrosivity 1-BP. Heat-separated human epidermal membranes were mounted on static diffusion cells. Different exposure scenarios studied (infinite dose, finite transient exposure) using neat 1-BP saturated aqueous solution donor. Steady-state fluxes for infinite-dose averaged 625 960 μg cm(-2) h(-1). finite-dose (10 μl/cm(2) = 13.5 mg/cm(2)) unoccluded donor resulted in penetration <0.2% applied dose (22 μg/cm(2)). A 10-min infinite total 179 μg/cm(2). from application similar (441 722 h(-1)). permeability coefficient water vehicle 0.257 ± 0.141 cm/h. potential following dependent upon type duration exposure. Donor losses due evaporation approximately 500-fold greater than flux; flux 420 mg cytotoxic but not corrosive, based results cultured reconstructed model (EpiDerm Skin Corrosivity Test).
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