Sex and androgenic steroid receptor expression in hepatic adenomas

摘要: Sex hormones and anabolic-androgenic steroids are implicated in the development progression of hepatic adenomas (HA). We studied expression their receptors HA adjacent liver. Archival tissue sections 27 (16 resections, four needle biopsies, seven aspirations) from 18 patients, liver, were immunostained with monoclonal antibody to estrogen receptor (ER, 1/80) (Dako, Carpinteria, CA), progesterone (PR, 1/50) (BioGenex, San Ramon, androgen (AR, (BioGenex). An avidin-biotin complex technique was used microwave antigen retrieval. Nuclear assessed as 1+ 3+ intensity, semiquantitation percentage nuclei immunopositive. Five percent or more immunopositive regarded positive. The patients included 16 females 34 years mean age (range, 49) an available history oral contraceptives five; two men 24 30 years, no androgenic steroids. ER, PR, AR present (26%) (1+/-2+ 5% 10% nuclei) HA, 30% nine (33%) (1+/-3+ 80% nuclei), respectively. In liver 11 cases, there one (9%) (2+ (36%) PR 20% (18%) (2+/-3+ nuclei). Receptors may mediate action sex on but less than third patients. This have therapeutic implications.