Multidrug resistance 3 gene mutation 1712delT and estrogen receptor α gene polymorphisms in Finnish women with obstetric cholestasis

摘要: Abstract Objective : To investigate the contribution of estrogen receptor α ( ERα ) polymorphism in development obstetric cholestasis and to determine whether multidrug resistance 3 MDR3 gene 1712delT mutation detected French patients is also present Finnish women with cholestasis. Study design In a retrospective case-control study, two polymorphisms were investigated healthy control N =47) diagnosis obsteric =57). Pvu II Xba I evaluated genomic DNA by using polymerase chain reaction (PCR). addition, frequencies general population our area are presented for comparison. Results None genotypes or alleles was significantly over-represented When analyzed parallel, six genotype combinations recognized, distribution these did not reveal statistically significant differences between cases controls P =0.612). No patient heterozygous homozygous mutant allele gene. Conclusion The data indicate that unlikely play any role affected women. Further work identify explanatory factors particular interest.