Intrahepatic Cholestasis of Pregnancy.

摘要: Intrahepatic cholestasis of pregnancy (or obstetric cholestasis) is a liver disorder that occurs in late pregnancy. Despite the potential adverse maternal and fetal/neonatal outcomes, often neglected treated expectantly. More research needed to improve molecular genetic understanding disease define safe effective medical treatment improves clinical outcome. Ursodeoxycholic acid considered be option third trimester, but further randomized controlled trials are before ursodeoxycholic can generally recommended. preferentially administered patients with severe (onset week 33 or serum bile levels > 70 mmol/L) history sudden fetal death, while maintaining close regular biochemical surveillance (transaminases, bilirubin, levels). decrease pruritus ameliorate tests, effects on complications ambiguous. S-Adenosylmethionine, dexamethasone, cholestyramine provide some relief itching. Because none these drugs have been shown harmful mother fetus, individual woman her clinician may decide whether try one treatments described.