The molecular genetics of intrahepatic cholestasis of pregnancy.
作者： P H Dixon , C Williamson
关键词:
摘要: Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, causes maternal pruritus and liver impairment, may be complicated by spontaneous preterm labour, fetal asphyxial events intrauterine death. Our understanding the aetiology this disease has expanded significantly in last decade due to a better role played genetic factors. In particular, advances our knowledge bile homeostasis led identification genes that play considerable susceptibility ICP. review we consider these discuss context synthesis metabolism, focusing on discoveries have shed light molecular pathophysiology condition.
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