Obstetric cholestasis, outcome with active management: a series of 70 cases

摘要: Abstract Objective To determine the nature and outcome of obstetric cholestasis in a United Kingdom population. Design Prospective analysis clinical women diagnosed with that is actively managed. Setting Antenatal population three London hospitals between August 1999 April 2001. Population Seventy defined as abnormal liver function (one or more abnormality gamma-glutamyl transpeptidase, alanine amino-transferase, aspartate amino-transferase total bile acids) pregnant woman pruritus, absence other pathology. Methods All were interviewed weekly regarding their symptoms. managed according to standardised protocol, which included early delivery before 38 weeks. Obstetric was recorded. Results mean age 30 (6) years delivered 73 infants. The median gestation at onset pruritus (range 4–39) weeks diagnosis 33.7 21–40.7) Asian likely be cholestasis. Pruritus usually severe generalised, commonly worst on palms and/or soles feet. There no stillbirths perinatal deaths. Twenty-five required caesarean section (36%); only four (16%) for fetal distress. Twelve (17%) 37 weeks, eight (67%) iatrogenic. Ten (14%) infants admission special care baby unit (40%) ventilated. Conclusions Policies active management result increased intervention associated complications. This must balanced against possible reductions mortality.