Cutaneous soft tissue sarcoma incidence patterns in the U.S. : an analysis of 12,114 cases.

摘要: BACKGROUND. Cutaneous soft tissue sarcomas (CSTS) are a heterogeneous group of mesenchymal neoplasms. To the authors' knowledge, no prior large, population-based study has focused on CSTS. METHODS. Surveillance, Epidemiology, and End Results (SEER) Program incidence relative survival rates CSTS were analyzed according to race, sex, histologic type using 2002 criteria World Health Organization classification. RESULTS. Among residents 13 SEER registries, 12,114 diagnosed from 1992 through 2004. Overall age-adjusted highest among blacks (30.8 per 1,000,000 person-years) followed by whites (25 person-years), American Indians/Alaska Natives (11.2 lowest Asian/Pacific Islanders (7.7 person-years). Kaposi sarcoma (KS) accounted for 71.1% cases, similarly ranked. Dermatofibrosarcoma protuberans (DFSP) also blacks, whereas leiomyosarcoma (LS) angiosarcoma (AS) whites. The rate ratio men women was 25.5 KS, 4.7 malignant fibrous histiocytoma (MFH), 3.7 LS, 2.0 AS, 0.9 DFSP. 5-year 99% patients with DFSP, 89% MFH, 92% 45% AS. KS in original 9 registries increased more than 30-fold during 1980s before they peaked around 1991 subsequently declined rapidly because human immunodeficiency virus-associated highly active antiretroviral therapy. This pattern evident not only those ages 20 59 years but 60 69 years. From 1978 2004, LS AS exponentially. CONCLUSIONS. CSTS varied markedly over time type, supporting notion that these variants areetiologically distinct. Cancer 2008. © 2008 Society.