Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species.
作者： C.H.V. Hoyle , J. Hill , G.J. Sanger , P.L.R. Andrews
DOI: 10.1016/S0167-0115(03)00113-7
关键词:
摘要: Pancreatic polypeptide was isolated and sequenced from endocrine cells of the pancreas an insectivore, house musk shrew, Suncus murinus. The primary sequence APLEPAYPGD(10)NATPEQMAQY(20)AAELRKYINM(30)VTRPRYamide. This is first hormone to be characterised this species typical sequences pancreatic other animals, being a C-terminal-amidated peptide with 36 residues. Comparison several vertebrate shows that it has more in common human form than do forms laboratory animals such as rabbits, rats, mice guinea-pigs.
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