Enteric-coated layered double hydroxides as a controlled release drug delivery system
作者： Bingxin Li , Jing He , David G. Evans , Xue Duan
DOI: 10.1016/J.IJPHARM.2004.08.016
关键词:
摘要: Layered double hydroxides (LDHs) or so-called anionic clays consist of cationic brucite-like layers and exchangeable interlayer anions. Because their biocompatibility, these layered inorganic solids can be used as host materials to create drug-LDH host-guest supramolecular structures. the basicity LDHs however, drug delivery system will limited for use in stomach where pH is 1.2. A core-shell material has been prepared therefore this work. non-steroidal anti-inflammatory drug, Fenbufen-intercalated core was coated with enteric polymers, Eudragit S 100 L a shell, giving composite which shows controlled release under vitro conditions model passage through gastrointestinal tract.
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