Safety and effectiveness of propranolol in severely burned patients: systematic review and meta-analysis.

摘要: The objective of this systematic review was to determine the effectiveness and safety propranolol compared placebo or usual care for improving clinical relevant outcomes in severely burned patients (TBSA >20%). Relevant articles from randomized controlled trials were identified by a literature search MEDLINE, EMBASE, CENTRAL. We included involving with severe burn (>20% total body surface area affected). Trials eligible if they evaluated placebo. Two investigators independently assessed inclusion exclusion criteria selected studies final analysis. conducted meta-analysis using random-effects model. ten our review. These 1236 participants. There no significant differences between respect mortality (RD −0.02 [95% CI −0.06 0.02]), sepsis −0.03 −0.09 0.04]), overall hospital stay (MD −0.37 [−4.52 3.78]). Propranolol-treated adults had decrease requirements blood transfusions −185.64 −331.06 −40.43]) decreased heart rate −26.85 −39.95 −13.75]). Our analysis indicates that there treated those who However, use these resulted lower transfusion values rate. evidence synthesized is limited conclude reduces length among patients. Future should assess impact on clinically such as adverse events.