Epigenetic biomarkers for early detection, therapeutic effectiveness, and relapse monitoring of cancer
作者： Rafael Guerrero-Preston , Mario Fraga , Esteban Ballestar , Manuel Esteller
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摘要: The present invention provides methods of detection, including early for cancer or other diseases and normal physiologic processes mediated by global epigenetic changes, using one more the following biomarkers: a DNA methylation index, histone H4 acetylation trimethylation index. These are useful for, among things, assessing effectiveness treatment, monitoring relapse, clinical staging chronic as well acute diseases. also things strategies therapies used to modify lifestyle contextual effects prevent disease, foster wellness enable health promotion.
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