Risk of Lung Cancer Among White and Black Relatives of Individuals With Early-Onset Lung Cancer

摘要: ContextEvidence exists that lung cancer aggregates in families and recent findings of a chromosomal region linked to susceptibility support genetic component risk. Family studies of early-onset patients offer a unique opportunity evaluate lifetime risk relatives.ObjectiveTo measure aggregation estimate among relatives cases population-based controls.Design SettingFamilial cumulative estimates from interview data of incident concurrently ascertained controls between 1990 2003 in metropolitan Detroit, Mich.ParticipantsThe study included 7576 biological mothers, fathers, siblings of 692 773 frequency-matched controls. One third the population was black.Main Outcome MeasuresCumulative cancer, stratified by race smoking behavior relatives controls.ResultsSmokers with family history first-degree relative had higher developing increasing age than smokers without history. An increase occurs after 60 years these individuals, 17.1% (SE 2.4%) white case and 25.1% 5.8%) black diagnosed age 70 years. Relatives were at statistically significant increased risk compared (odds ratio, 2.07, 95% confidence interval, 1.29-3.32) adjusting for age, sex, pack-years, pneumonia, chronic obstructive disease.ConclusionsFirst-degree individuals cancer have greater than their counterparts, these risks are further amplified cigarette smoking. These data provide estimates of can be used offer counseling members of cancer.