BDNF as a Promising Therapeutic Agent in Parkinson's Disease.

摘要: Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration. In animal models of Parkinson’s disease (PD), BDNF enhances the survival dopaminergic neurons, improves neurotransmission motor performance. Pharmacological therapies PD are symptom-targeting, their effectiveness decreases with progression disease; therefore, new therapeutical approaches needed. Since, in both patients models, decreased level was found nigrostriatal pathway, it has been hypothesized that may serve as a therapeutic agent. Direct delivery exogenous into patient’s brain did not relieve symptoms disease, nor attempts to enhance expression gene therapy. Physical training neuroprotective PD. This effect is mediated, at least partly, by BDNF. Animal studies revealed physical activity increases tropomyosin receptor kinase B (TrkB) expression, leading inhibition neurodegeneration through induction transcription factors genes related neuronal proliferation, survival, inflammatory response. review focuses on evidence increasing due modulation or exercise could be considered adjunctive therapy