Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

作者: Kristin J. Lastwika , Willie Wilson , Qing Kay Li , Jeffrey Norris , Haiying Xu

DOI: 10.1158/0008-5472.CAN-14-3362

关键词:

摘要: Alterations in EGFR, KRAS, and ALK are oncogenic drivers in lung cancer, but how oncogenic signaling influences immunity in the tumor microenvironment is just beginning to be …

参考文章(51)
Haidong Dong, Gefeng Zhu, Koji Tamada, Lieping Chen, B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion Nature Medicine. ,vol. 5, pp. 1365- 1369 ,(1999) , 10.1038/70932
Leisa Johnson, Kim Mercer, Doron Greenbaum, Roderick T. Bronson, Denise Crowley, David A. Tuveson, Tyler Jacks, Somatic activation of the K-ras oncogene causes early onset lung cancer in mice Nature. ,vol. 410, pp. 1111- 1116 ,(2001) , 10.1038/35074129
M C Hollander, C R Maier, E A Hobbs, A R Ashmore, R I Linnoila, P A Dennis, Akt1 deletion prevents lung tumorigenesis by mutant K-ras Oncogene. ,vol. 30, pp. 1812- 1821 ,(2011) , 10.1038/ONC.2010.556
Courtney A. Granville, Regan M. Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn LoPiccolo, Jason Foley, David J. Liewehr, Seth M. Steinberg, Daniel H. Fowler, M. Christine Hollander, Phillip A. Dennis, A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis PLoS ONE. ,vol. 4, pp. e5061- ,(2009) , 10.1371/JOURNAL.PONE.0005061
Jennifer M. Boland, Eugene D. Kwon, Susan M. Harrington, Jason A. Wampfler, Hui Tang, Ping Yang, Marie Christine Aubry, Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung Clinical Lung Cancer. ,vol. 14, pp. 157- 163 ,(2013) , 10.1016/J.CLLC.2012.05.006
Patricia S. Hähnel, Sonja Thaler, Edite Antunes, Christoph Huber, Matthias Theobald, Martin Schuler, Targeting AKT Signaling Sensitizes Cancer to Cellular Immunotherapy Cancer Research. ,vol. 68, pp. 3899- 3906 ,(2008) , 10.1158/0008-5472.CAN-07-6286
Edward B Garon, Naiyer A Rizvi, Rina Hui, Natasha Leighl, Ani S Balmanoukian, Joseph Paul Eder, Amita Patnaik, Charu Aggarwal, Matthew Gubens, Leora Horn, Enric Carcereny, Myung-Ju Ahn, Enriqueta Felip, Jong-Seok Lee, Matthew D Hellmann, Omid Hamid, Jonathan W Goldman, Jean-Charles Soria, Marisa Dolled-Filhart, Ruth Z Rutledge, Jin Zhang, Jared K Lunceford, Reshma Rangwala, Gregory M Lubiniecki, Charlotte Roach, Kenneth Emancipator, Leena Gandhi, None, Pembrolizumab for the treatment of non-small cell lung cancer The New England Journal of Medicine. ,vol. 372, pp. 2018- 2028 ,(2015) , 10.1056/NEJMOA1501824
P. Loke, J. P. Allison, PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 5336- 5341 ,(2003) , 10.1073/PNAS.0931259100