Impact of psychiatric comorbidity and cognitive deficit on function in 22q11.2 deletion syndrome.

摘要: OBJECTIVE Presence of psychiatric comorbidity is associated with poor functioning and an important consideration in treatment. Many individuals 22q11.2 deletion syndrome (22q11DS) develop comorbid disorders, yet its pattern impact on have not been formally investigated. In this cross-sectional study, we examined the relationship between psychopathology neurocognitive deficits their association global functioning. We hypothesized that higher burden psychosis-spectrum features would be reduced increased deficits. METHOD The cohort included 171 22q11DS mean (SD) age 17.4 (8.1) years, recruited from a tertiary children's hospital nationally through social media September 2010 December 2013. Psychiatric diagnoses were assessed using semistructured interviews Global Assessment Functioning (GAF) scale, respectively. On basis number diagnoses, participants assigned to unaffected (n = 32), nonpsychosis spectrum 24), spectrum-plus 15), psychosis 29), 71) groups. Executive function, episodic memory, complex cognition, praxis speed computerized battery (CNB). Cognitive profile GAF scores compared among groups, cognitive performance was examined. RESULTS observed high rates disorders. Approximately 50% had ≥ 2 diagnoses. Psychosis disorders most frequently other score progressively worse burden. Mean for group (81.1 [8.9]) significantly different those (68.6 [12.1]), (63.4 [8.8]), (58.7 [13.1]), or (55.5 [13.3]) (P < .05) All groups performed poorly comparable each CNB .273). Notably, verbal memory .003), spatial processing .001), parent education level .001) GAF. CONCLUSIONS Individuals diffuse regardless Those psychotic are at risk overall