Breast ductal carcinoma in situ (DCIS): Reproductive and hormonal risk factors and reliability of histologic diagnoses
作者： Lynette S. Phillips
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摘要: Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous disease with no single histopathologic classification system. It unclear which features pathologists use to categorize DCIS clinical practice, and consistency categorization among unknown. Five from separate North Carolina hospitals rated 53 slides on overall (comedo or non-comedo type DCIS), pattern necrosis (central/comedo-type, punctate/individual cell, absent) maximum nuclear diameter determine inter-observer reliability using kappa (κ) statistic. Agreement diagnosis was moderate (κ=0.48, 95% CI=0.41-0.55), while fair for (κ=0.35, CI=0.30-0.41) (κ=0.22, CI=0.16-0.28). These results indicate inconsistency add growing evidence that universal system needed ensure accurate, reliable diagnoses. Introduction As U.S. incidence rates ductal have increased increase mammographic screening early 1980s, struggled define disease. are malignant tumors confined lactiferous ducts, without stromal invasion across basement
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