Human Osteosarcoma Cell Lines Are Dependent on Insulin-like Growth Factor I for in Vitro Growth

摘要: Osteogenic sarcoma is the most common bone tumor of childhood and typically occurs during adolescent growth spurt when hormone insulin-like factor I (IGF-I) may be at their lifetime highest levels. Since IGF-I involved in normal differentiation, we have evaluated possible role signaling human osteogenic cell lines. In this study, demonstrate that vitro survival cells dependent on exogenously supplied IGF-I. Furthermore, show these display functional receptors surface inhibited by blocking either monoclonal antibodies or antisense oligonucleotides. These data lines are through receptor for proliferation. they suggest modulation hormone/IGF-I axis affect tumors vivo.