Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling.

摘要: Chimaphilin, an active compound separated from pyrola, possesses the highly efficient antitumor activities. Insulin-like growth factor-I receptor (IGF-IR) plays important role in tumor cell survival. To look for effective strategies interrupting IGF-IR signaling pathway, we found that chimaphilin can inhibit tyrosine kinase activity of IGF-IR. Chimaphilin inhibited both drug-sensitive and drug-resistant osteosarcoma lines a time dose-dependent manner; however, it showed relatively little toxicity normal osteoblast lines. increase sensitivity doxorubicin doxorubicin-resistant Additionally, small interfering RNA downregulation expression also caused resensitization to doxorubicin. Above all, conclude represents valuable natural source may potentially be applicable reversing phenotype therapy.