Associations between inherited thrombophilias, gestational age, and cerebral palsy

摘要: Objective This study was undertaken to investigate associations between inherited thrombophilic polymorphisms and cerebral palsy (CP) in a large case-control study. Study design is population-based Genomic DNA from newborn screening cards of 443 white CP cases 883 controls tested for factor V Leiden (FVL, G1691A), prothrombin gene mutation (PGM, G20210A), methylenetetrahydrofolate reductase (MTHFR) C677T MTHFR A1298C. Results associated with an increased risk developing any (32-36 weeks' gestation, homozygous odds ratio [OR] 2.55, 95% CI 1.12-5.74; heterozygous OR 1.91, 1.01-3.66). also diplegia at both less than 32 gestation (homozygous 2.76, 1.21-6.12) all gestations (heterozygous 1.58 95%, 1.02-2.45). For children weeks, FVL homozygosity may be increase the quadriplegia (OR 9.12, 0.86-53.71). A1298C (heterozygous) reduced 36 0.16, 0.02-0.70). There were no type thrombophilia born 37 weeks or greater. Heterozygous PGM combined gestational ages 5.33, 1.06-23.25). Conclusion approximately doubles preterm infants. A combination increases 5-fold ages.