Is thrombophilia a factor in the development of hemiplegic cerebral palsy

作者: Robert A Smith , Martin Skelton , Martin Howard , Malcolm Levene

DOI: 10.1017/S0012162201001323

关键词: PsychologyThrombophiliaHemiplegic cerebral palsyMean ageEtiologyPhysical therapyPopulationPediatrics

摘要: A population-based study of children with hemiplegic cerebral palsy (CP) was performed to investigate whether thrombophilic tendencies are implicated in the aetiology condition. Thirty-eight (23 males, 15 females; mean age 8.7 years, SD 4.1 years) CP were ascertained. Twenty-seven children(18 nine 8.4 4.3) gave consent for inclusion. The non-study group comprised five males and six 9.4 4.1. In children, seven 'abnormalities' identified. Five these abnormalities an equivocal nature probably did not represent true clinical thrombophilia; reasons this interpretation discussed. Contrary other published non-population-based studies, we have shown association between thrombophilia CP. More including maternal required explore complex subject further.

参考文章(32)
Chrzanowski R, Deonna T, Claeys, Congenital hemiparesis: the spectrum of lesions. A clinical and computerized tomographic study of 37 cases. Helvetica paediatrica acta. ,vol. 38, pp. 439- 455 ,(1983)
Fritz R Rosendaal, Thrombosis in the Young: Epidemiology and Risk Factors. A Focus on Venous Thrombosis Thrombosis and Haemostasis. ,vol. 78, pp. 1- 6 ,(1997) , 10.1055/S-0038-1657492
R K Silver, S E Neely, S N MacGregor, J F Pasternak, Fetal stroke associated with elevated maternal anticardiolipin antibodies. Obstetrics & Gynecology. ,vol. 80, pp. 497- 499 ,(1992)
P W Wong, A Horwitz, H G Bock, S S Kang, A Grix, Intermediate hyperhomocysteinemia resulting from compound heterozygosity of methylenetetrahydrofolate reductase mutations. American Journal of Human Genetics. ,vol. 48, pp. 546- 551 ,(1991)
Michael D. Lockshin, Pregnancy Loss in the Antiphospholipid Syndrome Thrombosis and Haemostasis. ,vol. 82, pp. 641- 648 ,(1999) , 10.1055/S-0037-1615891
Fiona J Stanley, Eve Blair, Eva Alberman, Eva Dorothea Alberman, Cerebral Palsies: Epidemiology and Causal Pathways ,(2000)
F.R. Rosendaal, Risk factors for venous thrombotic disease. Thrombosis and Haemostasis. ,vol. 82, pp. 610- 619 ,(1999) , 10.1055/S-0037-1615887
B Brenner, Thrombophilia and fetal loss Blood Reviews. ,vol. 11, pp. 72- 79 ,(1997) , 10.1016/S0268-960X(97)90013-8
Ottar Nygård, Stein Emil Vollset, Helga Refsum, Inger Stensvold, Aage Tverdal, Jan Erik Nordrehaug, Per Magne Ueland, Gunnar Kvåle, Total Plasma Homocysteine and Cardiovascular Risk Profile JAMA. ,vol. 274, pp. 1526- 1533 ,(1995) , 10.1001/JAMA.1995.03530190040032