Transplantation of enteric cells into the aganglionic rodent small intestines.
作者： Carrie L. Geisbauer , Benjamin M. Wu , James C.Y. Dunn
DOI: 10.1016/J.JSS.2011.05.014
关键词:
摘要: Background Enteric cells, a mixture of cells isolated from the longitudinal and circular muscle gut, may contain neural crest stem (NCSCs) therefore be potential source to regenerate enteric nervous system. Materials Methods Benzylalkonium chloride (BAC) was employed ablate myenteric submucosal plexi rodent jejunum. were then injected into this BAC-treated segment jejunum either with or without basic fibroblast growth factor (bFGF) mixed in collagen. Results Expression peripherin, S100, synaptophysin found all cell injection sites. Peripherin S100 expression appeared close proximity ganglion-like structures when bFGF simultaneously cells. Synapses that formed presence elongated compared those absence exogenously delivered bFGF. A small percentage expressed peripherin site after transplantation. Conclusions transplanted collagen an aganglionic regenerated hold as cellular therapeutic for various motility disorders gastrointestinal tract.
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sci-hub.se 参考文章(48)
J.B Furness, Types of neurons in the enteric nervous system. Journal of The Autonomic Nervous System. ,vol. 81, pp. 87- 96 ,(2000) , 10.1016/S0165-1838(00)00127-2
W. J. Pavan, R. A. Liddell, A. Wright, G. Thibaudeau, P. G. Matteson, K. M. McHugh, L. D. Siracusa, A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease Mammalian Genome. ,vol. 6, pp. 1- 7 ,(1995) , 10.1007/BF00350885
C. I. Hagl, M. Klotz, E. Wink, K. Kränzle, S. Holland-Cunz, N. Gretz, M. Diener, K. H. Schäfer, Temporal and regional morphological differences as a consequence of FGF-2 deficiency are mirrored in the myenteric proteome Pediatric Surgery International. ,vol. 24, pp. 49- 60 ,(2008) , 10.1007/S00383-007-2041-4
Peter G. C. Bannerman, Rhona Mirsky, Kristjàn R. Jessen, Rupert Timpl, Victor C. Duance, Light microscopic immunolocalization of laminin, type IV collagen, nidogen, heparan sulphate proteoglycan and fibronectin in the enteric nervous system of rat and guinea pig. Journal of Neurocytology. ,vol. 15, pp. 733- 743 ,(1986) , 10.1007/BF01625191
Jack T. Mosher, Kelly J. Yeager, Genevieve M. Kruger, Nancy M. Joseph, Mark E. Hutchin, Andrzej A. Dlugosz, Sean J. Morrison, Intrinsic differences among spatially distinct neural crest stem cells in terms of migratory properties, fate-determination, and ability to colonize the enteric nervous system Developmental Biology. ,vol. 303, pp. 1- 15 ,(2007) , 10.1016/J.YDBIO.2006.10.026
Genevieve M. Kruger, Jack T. Mosher, Yu-Hwai Tsai, Kelly J. Yeager, Toshihide Iwashita, Cheryl E. Gariepy, Sean J. Morrison, Temporally Distinct Requirements for Endothelin Receptor B in the Generation and Migration of Gut Neural Crest Stem Cells Neuron. ,vol. 40, pp. 917- 929 ,(2003) , 10.1016/S0896-6273(03)00727-X
John B. Furness, The organisation of the autonomic nervous system: peripheral connections. Autonomic Neuroscience: Basic and Clinical. ,vol. 130, pp. 1- 5 ,(2006) , 10.1016/J.AUTNEU.2006.05.003
Maria-Adelaide Micci, Pankaj Jay Pasricha, Neural stem cells for the treatment of disorders of the enteric nervous system: Strategies and challenges Developmental Dynamics. ,vol. 236, pp. 33- 43 ,(2007) , 10.1002/DVDY.20975
Kiminori Hosoda, Robert E. Hammer, James A. Richardson, Amy Greenstein Baynash, Jason C. Cheung, Adel Giaid, Masashi Yanagisawa, Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice Cell. ,vol. 79, pp. 1267- 1276 ,(1994) , 10.1016/0092-8674(94)90017-5
H.M. Young, C.J. Hearn, D. Ciampoli, B.R. Southwell, J.-F. Brunet, D.F. Newgreen, A Single Rostrocaudal Colonization of the Rodent Intestine by Enteric Neuron Precursors Is Revealed by the Expression of Phox2b, Ret, and p75 and by Explants Grown under the Kidney Capsule or in Organ Culture Developmental Biology. ,vol. 202, pp. 67- 84 ,(1998) , 10.1006/DBIO.1998.8987