Effect of Hypoxia/Ischemia on Bicuculline‐Induced Seizures in Immature Rats: Behavioral and Electrocortical Phenomena

摘要: The relation between hypoxia/ischemia and subsequent alterations in seizure susceptibility developing brain remains unclear. We assessed the behavioral electrocorticographic (ECoG) effects of hypoxic/ischemic damage on bicuculline (BIC)-induced seizures 7-day postnatal rats, determined maturational changes susceptibility, behavior ECoG activity. Rat pups were subjected to unilateral common carotid artery ligation, followed by exposure 8% O2 at 37 degrees C for 2 h, an insult that produces cerebral hemisphere ipsilateral occlusion. experimental group consisted rat previously hypoxia/ischemia; control littermates received neither arterial ligation nor systemic hypoxia. Experimental animals 4, 5, or 6 mg/kg BIC subcutaneously (s.c.) 24 3, 7, 21 days recovery from hypoxia/ischemia. Two each interval recovery, 1 groups, used monitoring. After injection, animal was observed h. Behaviors classified five categories based severity, duration, character: 1, mild irritability; 2, few clonic agitation; tonic-clonic with swimming movements; frequent apneic episodes; continuous death. had lesser than controls 2-h (p < 0.05) greater h 0.05). Tonic prominent both whereas lesion-sided circling only pups.(ABSTRACT TRUNCATED AT 250 WORDS)