[Relationship between the effects of a high-fat meal and blood group in determination of alkaline phosphatase activity].

作者: Tsugikazu Komoda , Makoto Matsushita

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摘要: We previously reported that two isoforms of intestinal alkaline phosphatase (IAP) are present in the serum, a high-molecular-weight isoform(HIAP) and normal-molecular-weight isoform (NIAP), both at high levels blood group B or O secretors. In paper, we investigated relationship between effects high-fat meal groups on ALP activity. Subjects fasted for 14 hours after dinner previous evening ate following morning. Two types meals were prepared; low-calorie (470 kcal), high-calorie (950 kcal). 2 different days. Blood was collected 3 times; once preprandially, 6 h postprandially. Among secretors (n = 24), mean +/- SD increase activity 26.4 10.2 U/L 23.3 9.0 postprandially, respectively, meal, 47.9 19.9 55.1 21.9 meal. Thus, increased 2-fold Similarly, among subjects with other 28), 5.7 3.7 4.2 3.1 8.5 5.2 10.6 6.0 significant differences seen (p < 0.001). The increases nearly identical to NIAP These results suggest is more likely affect secretors, this effect peaks Taken together, indicate that, as rule, samples determining should be early morning patient state.

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