Platelets and Immunity

摘要: Over the last several decades, a new paradigm of platelet function has evolved. Platelets, long forgotten hemostatic cells, were demonstrated to be versatile immune effector cells engaged in every compartment system. Platelets express multiple receptors, such as toll-like allowing them sense both pathogen- and danger-associated signals. Upon activation, platelets release large array biologically active molecules, like cytokines, chemokines, growth factors, many which are delivered platelet-derived microparticles. Rich transcriptome allows for signal-dependent translation protein synthesis, considered main source circulating microRNA. avidly interact with endothelial neutrophils, monocytes particular. shown propagate modulate inflammatory response other sterile diseases, atherosclerosis metabolic acute lung injury, ischemia reperfusion, autoimmune diseases. directed sites infection directly pathogens. They contribute elimination pathogens by phagocytosis, microbicidal peptides, signaling cells. Their interaction neutrophils triggers neutrophil extracellular traps, potent mechanism entrap bacteria flowing blood. recently involved adaptive immunity possibly link innate responses together. Fast bloodstream, readily available cellular interactions, able signals from damaged tissue, packed mediators, arise sentinels forming an integral part our