Exogenous obestatin decreases beta-cell apoptosis and alfa-cell proliferation in high fat diet and streptozotocin induced type 2 diabetic rats.

摘要: Abstract Type 2 diabetes is a chronic metabolic disease characterized by progressive decrease of islet cell function. Delaying the process failure remains challenging goal in care. Previous studies have confirmed role obestatin, gut peptide that belongs to ghrelin family, mediation glucose metabolism. This study aimed observe long term effects exogenous obestatin on metabolism type rat model. diabetic model was set up high-fat diet (60%) followed low dose streptozotocin intra-peritoneal injection. Exogenous administered at 20 nmol/kg for 12 weeks intraperitoneal Compared placebo group (saline injection), treatment decreased glucagon levels and increased c-peptide levels. Furthermore, led significant restoration morphology, increasing insulin reducing expressions. Apoptosis assay showed reduction number TUNEL positive-cells. The up-regulation Akt GSK3β pancreas Real-Time PCR. These results demonstrated might potential therapeutic relevance improving function, including secretion through inhibiting beta apoptosis decreasing alfa proliferation diabetes. In spite its these phenomena, it necessary further discuss, especially regarding glucagon.