GANT-like gastrointestinal pacemaker cell tumours with oncocytic features.

摘要: We describe two cases of gastrointestinal stromal tumours with prominent oncocytic features. Both had features consistent differentiation towards the interstitial cells Cajal (CC). They were composed nests and bundles abundant, deeply granular, eosinophilic cytoplasm. Immunohistochemical investigations revealed positivity c-kit, vimentin CD34 antibodies in both neoplasms. Ultrastructurally neoplastic showed characteristic CC; they synapse-like structures dense core cytoplasmic granules. Oncocytic confirmed by immunohistochemistry using anti-mitochondrion antibody electron microscopy one case (case 1). Although CC are frequently described as mitochondrion-rich cells, changes have not previously been reported a feature autonomic nerve tumour (GANT)-like tumours.