The effect of simulated gastric environments on the anti-Helicobacter activity of garlic oil.

摘要: Aims:  To investigate the effects of simulated gastric conditions upon anti-Helicobacter pylori garlic oil (GO). Methods and Results:  Time course viability experiments assessed anti-H. pylori activity GO (16 32 μg ml−1) in environments. Rapid action was observed artificial juice. Mucus (1–5%) strongly protective H. pylori both alone presence GO, but its effect antagonized by GO. Peptone (5–15 g l−1) caused a dose-dependent reduction Rapeseed (5·7–17 g l−1) greatly diminished Dextrin (44 133 g l−1) exhibited direct added to those Simulated meal mixtures decreased did not eliminate 32 μg ml−1 GO. Conclusions:  The noticeably affected food materials mucin. However, substantial remained under conditions. Further investigation therapeutic potential against is therefore warranted. Significance Impact Study:  Garlic may be useful as an alternative treatment H. pylori, major cause gastrointestinal infections humans.