High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen.
作者： Liang Cui , Wan Chan , Jian-Lin Wu , Zhi-Hong Jiang , Kelvin Chan
DOI: 10.1016/J.TALANTA.2007.12.045
关键词:
摘要: Metabolism and pharmacokinetic studies on rat were conducted for lithospermic acid B, one of the components from Radix Salviae Miltiorrhizae (danshen) that shows many bioactivities. Liquid chromatography-electrospray ionization mass spectrometry method was applied determination B its metabolites in samples vitro vivo metabolism studies. Rat plasma collected after intravenous administration analyzed obtaining data B. Four O-methylated metabolites, namely monomethyl-, two dimethyl- trimethyl-lithospermic detected when incubated hepatic cytosol. These four also bile, feces The results indicate methylation is main metabolic pathway danshen component methylated excreted to bile feces.
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Takashi TANAKA, Satoshi MORIMOTO, Gen-ichiro NONAKA, Itsuo NISHIOKA, Takako YOKOZAWA, Hae Young CHUNG, Hikokichi OURA, Magnesium and Ammonium-Potassium Lithospermates B, the Active Principles Having a Uremia-Preventive Effect from Salvia miltiorrhiza Chemical & Pharmaceutical Bulletin. ,vol. 37, pp. 340- 344 ,(1989) , 10.1248/CPB.37.340
Rena KASIMU, Ken TANAKA, Yasuhiro TEZUKA, Zhu-Nan GONG, Jian-Xin LI, Purusotam BASNET, Tsuneo NAMBA, Shigetoshi KADOTA, Comparative study of seventeen Salvia plants: aldose reductase inhibitory activity of water and MeOH extracts and liquid chromatography-mass spectrometry (LC-MS) analysis of water extracts. Chemical & Pharmaceutical Bulletin. ,vol. 46, pp. 500- 504 ,(1998) , 10.1248/CPB.46.500
J WU, L YEE, Z JIANG, Z CAI, One single LC–MS/MS analysis for both phenolic components and tanshinones in Radix Salviae Miltiorrihizae and its medicinal products Talanta. ,vol. 73, pp. 656- 661 ,(2007) , 10.1016/J.TALANTA.2007.04.038
Zongwei Cai, Achintya K. Sinhababu, Stephanie Harrelson, Simultaneous quantitative cassette analysis of drugs and detection of their metabolites by high performance liquid chromatography/ion trap mass spectrometry Rapid Communications in Mass Spectrometry. ,vol. 14, pp. 1637- 1643 ,(2000) , 10.1002/1097-0231(20000930)14:18<1637::AID-RCM73>3.0.CO;2-2
TAKAKO YOKOZAWA, TAE WOONG LEE, HAE YOUNG CHUNG, HIKOKICHI OURA, GEN-ICHIRO NONAKA, ITSUO NISHIOKA, Renal responses to magnesium lithospermate B. Journal of Pharmacy and Pharmacology. ,vol. 42, pp. 712- 715 ,(2011) , 10.1111/J.2042-7158.1990.TB06565.X
Katsuo Kamata, Mariko Noguchi, Masahiro Nagai, Hypotensive effects of lithospermic acid B isolated from the extract of Salviae miltiorrhizae Radix in the rat. General Pharmacology-the Vascular System. ,vol. 25, pp. 69- 73 ,(1994) , 10.1016/0306-3623(94)90011-6
Takahiro Nakazawa, Keisuke Ohsawa, Metabolism of Rosmarinic Acid in Rats Journal of Natural Products. ,vol. 61, pp. 993- 996 ,(1998) , 10.1021/NP980072S
Yinrong Lu, L Yeap Foo, Polyphenolics of Salvia—a review Phytochemistry. ,vol. 59, pp. 117- 140 ,(2002) , 10.1016/S0031-9422(01)00415-0
Dae Gill Kang, Hyuncheol Oh, Eun Jin Sohn, Tae Young Hur, Kang Chang Lee, Kwang Jin Kim, Tai Yo Kim, Ho Sub Lee, Lithospermic acid B isolated from Salvia miltiorrhiza ameliorates ischemia/reperfusion-induced renal injury in rats. Life Sciences. ,vol. 75, pp. 1801- 1816 ,(2004) , 10.1016/J.LFS.2004.02.034
Guilian Tian, Yabin Zhang, Tianyou Zhang, Fuquan Yang, Yoichiro Ito, Separation of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography using stepwise elution. Journal of Chromatography A. ,vol. 904, pp. 107- 111 ,(2000) , 10.1016/S0021-9673(00)00916-X