Immunotherapy for Medulloblastoma: Current Perspectives

摘要: Background Immune-mediated therapies have transformed the treatment of metastatic melanoma and renal, bladder, both small non-small cell lung carcinomas. However, immunotherapy is yet to demonstrate dramatic results in brain tumors like medulloblastoma for a variety reasons. Recent pre-clinical early phase human trials provide encouraging that may overcome challenges central nervous system (CNS) tumors, which include intrinsic immunosuppressive properties these cancers, lack antigen targets, antigenic variability, immune-restrictive site CNS. These studies highlight growing potential treat patients with medulloblastoma, disease frequent cause morbidity mortality children young adults. Methods We conducted an inclusive review PubMed-indexed literature listed clinicaltrials.gov using combinations keywords immunotherapy, CNS vaccines, oncolytic virus, natural killer, CAR T identify evaluating preclinical experiments or medulloblastoma. Given limited number investigations 24 were selected final analysis manuscript citation. Results This presents from lines, animal models, involving patients. Conclusion From our review, we suggest cancer viral therapy, killer cells, therapy hold promise against innate order prolong survival. There unmet need regimens target overexpressed antigens tumors. advocate more combination clinical conventional surgical radiochemotherapy approaches near-term development.