Detection of apoptosis and phagocytosis in vitro in C6 rat glioma cells treated with tiazofurin.
作者： V. Piperski , M. Vračar , M. Jokanović , P. Stukalov , L. Rakić
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摘要: Tiazofurin, an anticancer drug which inhibits IMP dehydrogenase activity and decreases GTP concentration in various malignant cells, induced inhibition of growth apoptosis C6 rat glioma vitro. The effects tiazofurin were significantly blocked by addition exogenous guanosine, suggesting the role decreased triggering specific signal transduction pathways involved cells. most interesting result this study was evidence phagocytosis apoptotic cells vitro neighbouring a phenomenon considered to occur only vivo. possibility observing suggests that cell system could be good model for studying mechanisms
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