Progesterone receptor binding of steroidal and nonsteroidal compounds

作者: Neelima M. Seth , A. P. Bhaduri

DOI: 10.1007/978-3-0348-9311-4_5

关键词:

摘要: Since the isolation of progesterone from corpus luteum in early 1930s, problem how elicits its specific physiological effect, has attracted both chemists and endocrinologists. The tissues which respond dramatically to this hormone are termed as target organs. progestational activity on organs been assayed vivo (Clauberg’s assay) it depends manner administration [1,2]. For example, progesterone, when administered orally, a low [1], possibly because metabolic inactivation steroid gastro-intestinal tract. Clauberg’s assay [3–5] received wide acceptance for almost two decades, late 1950s mid 1970s measurement was based method assay. efforts discover key points chemical structure responsible indeed In 1970, Milgrom Baulieu [6] observed that progesterone-binding macromolecule is present cytosol fraction rat uterus. existence similar binding specifically not non-progestational compounds uteri rat, rabbit guinea pig reported by other workers [7, 8] also.

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