Measurements of metastatic renal cell tumours as determined by diffusion weighted imaging or computed tomography are in close agreement, a pilot study

摘要: Abstract Background Diffusion weighted magnetic resonance imaging (DWI) provides both functional and anatomical information regarding tumours but can also be used for tumour detection. Today, treatment response in clinical trials is mainly assessed on Computed Tomography (CT) using established criteria. Despite availability of dedicated software, CT still requires significant manual work selection measurement evaluation solid tumours. Purpose To compare the maximum diameter lesions with corresponding measurements diffusion images. Materials methods In this prospective cohort, metastatic were identified DWI five patients renal cell carcinoma before after three months pazopanib. Two radiologists independently measured same axial images separately The compared between respect to number target measured, size lesions, reduction due inter-observer variability. Wilcoxon signed rank test, linear regression Bland-Altman plots statistical analyses. Results pilot study, there was no variability terms numbers lesion selected DWI. A observed when post-treatment scans pre-treatment scans. There difference pre- post (p = 0.099 p = 0.388 respectively). Conclusion Measurement basis are close agreement based conventional images, most often employed approach today. results study estimate sufficient sample a larger trial adequate power, confirmed wider range cancers other than carcinoma.