Regiodivergent halogenation of (E)-β-chlorovinyl ketones via soft α-vinyl enolization strategy.
作者： Hun Young Kim , Seokwoo Lee , Sanghee Kim , Kyungsoo Oh
DOI: 10.1021/OL5034354
关键词:
摘要: The soft α-vinyl enolization of (E)-β-chlorovinyl ketones was investigated in the presence various halogen electrophiles. Depending on nature electrophiles, selective formation three products, namely α,α-dichloropropargyl ketones, α,γ-dihaloallenyl and 3-halofurans, observed. observed regiodivergent nucleophilic pathways demonstrate diversity-oriented synthesis strategy which reactivity can be selectively modulated by choice suitable hard
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