Genetic topography of brain morphology

摘要: Animal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in influences on surface area an anterior-posterior axis using neuroimaging of adult human twins. Here, we demonstrate thickness a dorsal-ventral the same cohort. The phenomenon gradations organization evident different structural and functional properties may originate from gradients. Another emerging theme patterning patterns recapitulate spatial topography cortex within hemispheres. both corresponds to specializations. Intriguingly, contrast broad similarities patterning, two sets analyses distinguish genetically. First, contributions are distinct; there very little correlation (i.e., shared influences) between them. Second, organizing principles among genetically defined regions differ area. Examining structure similarity matrix clusters revealed that, whereas showed great proximity with lobe, appear have close relatedness similar maturational timing. discrepancies line evidence traits follow mechanisms neurodevelopment. Our findings highlight complexity morphology provide glimpse into cortex.