Striking Immunodominance Hierarchy of Naturally Occurring CD8+ and CD4+ T Cell Responses to Tumor Antigen NY-ESO-1

摘要: Immunodominance has been well-demonstrated in many antiviral and antibacterial systems, but much less so the setting of immune responses against cancer. Tumor Ag-specific CD8+ T cells keep cancer check via immunosurveillance shape tumor development through immunoediting. Because most Ags are self Ags, breadth depth antitumor have not well-appreciated. To design develop vaccines, it is important to understand immunodominance hierarchy its underlying mechanisms, identify immunodominant cells. We comprehensively analyzed spontaneous cellular one individual show that multiple targeted by patient's system, especially "cancer-testis" Ag NY-ESO-1. The pattern anti-NY-ESO-1 cell this patient closely resembles classical broad yet hierarchical immunity was confirmed a second subject.