作者: Baltazar Nunes , Pedro Pechirra , Anabela Coelho , Carlos Ribeiro , Ana Arraiolos
DOI: 10.1007/S00239-008-9154-9
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摘要: As a consequence of immune pressure, influenza virus hemagglutinin presents some its amino acids under positive selection. Several authors have reported the existence A codons selective pressure (PSP). In this framework, present work objectives were to demonstrate presence PSP and evaluate effects on Victoria- Yamagata-like B viruses. Methodology adopted consisted in estimating acceptance rate nonsynonymous substitutions (ω = dN/dS) that describe strength identifying may be positively selected, applying set continuous-time Markov chain codon-substitution models. Two groups HA1 sequences (140 from Yamagata 60 Victoria lineage) used. All model maximum-likelihood estimates obtained using codeml software application (PAML 3.15). The hypothesis no sites was rejected for both lineages (p 0.95 197 199 lineages, codon 75 lineage, 129 lineage. detected are located at or near antigenic H3 hemagglutinin.