摘要: The role of glial cells is to support and sustain proper neuronal function microglia are no exception this. This viewpoint article emphasizes the fundamental interdependence neurons takes a look at possibility what could happen if microglial became dysfunctional as result aging, genetics, or epigenetics. Could senescence be factor in pathogenesis Alzheimer's other neurodegenerative diseases? cautious answer that question 'yes'. Future studies along these lines may provide novel insights into involvement disease pathogenesis.
sci-hub.se 参考文章(54)
Gennadij Raivich, Microglial Response in the Axotomized Facial Motor Nucleus Springer, New York, NY. pp. 166- 187 ,(2002) , 10.1007/978-1-4757-4139-1_8
R. H. Christie, M. Freeman, B. T. Hyman, Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. American Journal of Pathology. ,vol. 148, pp. 399- 403 ,(1996)
M. Schroeter, S. Jander, I. Huitinga, G. Stoll, CD8+ phagocytes in focal ischemia of the rat brain: predominant origin from hematogenous macrophages and targeting to areas of pannecrosis. Acta Neuropathologica. ,vol. 101, pp. 440- 448 ,(2001) , 10.1007/S004010000304
D. W. Dickson, P. Davies, H. Crystal, S.-H. C. Yen, P. Fuld, J. Farlo, Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. American Journal of Pathology. ,vol. 132, pp. 86- 101 ,(1988)
A L Ford, W F Hickey, A L Goodsall, J D Sedgwick, Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. Journal of Immunology. ,vol. 154, pp. 4309- 4321 ,(1995)
Thomas Möller, Christiane Nolte, Reinhard Burger, Alexej Verkhratsky, Helmut Kettenmann, Mechanisms of C5a and C3a Complement Fragment-Induced [Ca2+]i Signaling in Mouse Microglia The Journal of Neuroscience. ,vol. 17, pp. 615- 624 ,(1997) , 10.1523/JNEUROSCI.17-02-00615.1997
Jianglin He, Youzhi Chen, Michael Farzan, Hyeryun Choe, Asa Ohagen, Suzanne Gartner, Jorge Busciglio, Xiaoyu Yang, Wolfgang Hofmann, Walter Newman, Charles R Mackay, Joseph Sodroski, Dana Gabuzda, None, CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia Nature. ,vol. 385, pp. 645- 649 ,(1997) , 10.1038/385645A0
G.M. Hayes, M.N. Woodroofe, M.L. Cuzner, Characterisation of microglia isolated from adult human and rat brain Journal of Neuroimmunology. ,vol. 19, pp. 177- 189 ,(1988) , 10.1016/0165-5728(88)90001-X
Wolfgang J. Streit, Takato Morioka, Audrey N. Kalehua, MK-801 prevents microglial reaction in rat hippocampus after forebrain ischemia. Neuroreport. ,vol. 3, pp. 146- 148 ,(1992) , 10.1097/00001756-199202000-00006
M. B. Graeber, W. J. Streit, G. W. Kreutzberg, Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells Journal of Neuroscience Research. ,vol. 21, pp. 18- 24 ,(1988) , 10.1002/JNR.490210104