Hazard Identification and Dose Response of Inhaled Nickel-Soluble Salts

摘要: A substantial body of occupational epidemiology data has shown that exposure to mixed soluble and insoluble nickel causes the development lung nasal cancer. However, due coexposure these populations forms nickel, limitations in measurements, contribution is difficult determine. Soluble was negative an NTP inhalation bioassay, while there some evidence for tumorigenicity rats less oxide, clear subsulfide rats. Results parenteral assays follow a similar pattern, but provide weak carcinogenicity nickel. Kinetic factors also indicate alone low carcinogenic potential. Overall, we conclude activity compounds should not be used predict potential water-soluble salts. The overall suggest nonlinear dose-response relationship carcinogenicity, are insufficient determine doses at which such nonlinearities occur. Under U.S. EPA's 1996 proposed "Guidelines Carcinogen Risk Assessment," inhaled would classified as "cannot determined," because existing composed conflicting data. reference concentration 2 x 10(-4) mg Ni/cu m calculated, based on fibrosis male observed study.