CD5 negative IGM rheumatoid factor B cells in B-chronic lymphocytic leukemia and benign mixed cryoglobulinemia.

摘要: IgM-RF B cell precursors are abnormally overrepresented in "well differentiated" lymphoid monoclonal proliferations while data on less mature malignancies still awaited. This nevertheless suggests that RF activity plays a role the transforming process perhaps by inducing constant stimulation of precursor cells. Despite preferential use similar VH and VL genes with little or no somatic hypermutations both malignant B-cell CLL nonmalignant mixed cryoglobulinemia, these do differ CD5 membrane expression their clinical evolution. One possibility could be glycoprotein is lost during maturation lymphocyte into secreting as suggested Waldenstrom's disease LES-CLL vitro studies. Alternatively, play an additional direct transformation recent receptor ligand. Further proliferating cells situations well genetic control its physiology should shed light mechanisms malignancy.